Li Q, Wang M, Tan L, Wang C, Ma J, Li N, Li Y, Xu G, and Li J. “Bioactive dietary long-chain fatty acids: emerging mechanisms of action.” Br J Nutr 100:1152-1157 (2008)ĩ. Chapkin RS, McMurray DN, Davidson LA, Patil BS, Fan YY, and Lupton JR. “Docosahexaenoic acid: membrane properties of a unique fatty acid. “Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid.” World Rev Nutr Diet 88:196-199 (2001)ħ. Sato M, Adan Y, Shibata K, Shoji Y, Sato H, and Imaizumi K. “EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials.” J Am Coll Nutr 28:525-542 (2009)Ħ. “Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography.” J Lipid Res 50:1259-1268 (2009)ĥ. Umhau JC, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, Hussein N, Bhattacharjee AK, Ma K, Esposito G, Majchrzak S, Herscovitch P, Eckelman WC, Kurdziel KA, and Salem N. “Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. “Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study.” Prostaglandins Leukot Essent Fatty Acids 80:157-163 (2009)ģ. Chen CT, Liu Z, Ouellet M, Calon F, and Bazinet RP. On the other hand, the myelin membrane is essentially an insulator so that relatively little DHA is found in that part of the membrane.ġ. This is why DHA is a critical component of these highly fluid portions of the nerves (7). This increase in membrane fluidity is critical for synaptic vesicles and the retina of the eye as it allows receptors to rotate more effectively thus increasing the transmission of signals from the surface of the membrane to the interior of the nerve cells. Although this increase in spatial volume makes DHA a poor substrate for phospholipase A2 as well as the COX and LOX enzymes, it does a great job of making membranes (especially those in the brain) a lot more fluid as the DHA sweeps out a much greater volume in the membrane than does EPA. 20 in EPA) means that DHA takes up a lot more space than does EPA in the membrane. five in EPA) and increased carbon length (22 carbons in DHA vs. As mentioned earlier, the extra double bond (six in DHA vs. In my opinion, the key benefit of DHA lies in its unique spatial characteristics. This is why if you use high-dose DHA it is essential to add back trace amounts of GLA to maintain sufficient levels of DGLA to continue to produce anti-inflammatory eicosanoids. This can be a disaster as a great number of powerful anti-inflammatory eicosanoids are derived from DGLA. Even though the reduction of GLA will eventually decrease AA production, it also has the more immediate effect of reducing the production of the next metabolite known as dihomo gamma linolenic acid or DGLA. However, this is not exactly an advantage. Whereas EPA is the inhibitor of the enzyme (D5D) that directly produces AA, DHA is an inhibitor of another key enzyme delta-6-desaturase (D6D) that produces the first metabolite from linoleic acid known as gamma-linolenic acid or GLA (6). The first difference is in the area of omega-6 fatty acid metabolism. Actually just the opposite, because DHA can do a lot of different things that EPA can’t do. Each softgel is filled to the brim with plenty of naturally extracted DHA- and EPA-rich algae oil.At this point, you might think that DHA is useless. Plus, Together Health grow the algae in a 100% contamination-free environment and extract the omega without using any chemicals at all. With an estimated 25% of the global fish catch being used to produce omega 3, Together Health is dedicated to only producing omega 3 that doesn’t contribute to the disruption of our delicate marine ecosystems.įish only contain omega 3 because they eat algae, so algae is a much more direct sustainable and environmentally friendly way for us to consume omega 3. Not only do fish oils have a strong scent and leave an overwhelming aftertaste, they also contribute to the problem of overfishing. Algae doesn’t contain any of the nasty contaminants found in fish oil, so it can be done in a sustainable way (the Together Health way). Together Health has taken all the goodness from one of nature’s finest offerings and sourced their omega 3 from pure, powerful algae. DHA to maintain normal vision & brain function.Natural sustainable fish-free algae source.
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